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References   References 2770  
Type : Journal
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Krämer I, Schwabe A, Lichtinghagen R, Kamin W.
Title : Physicochemical compatibility of nebulizable drug mixtures containing dornase alfa and ipratropium and/or albuterol.
Reference : Pharmazie ; 62, 10: 760-766. 2007
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
AerosolDornase alfa Various
Factors which affect stability Excipient Benzalkonium chloride Induces Degradation
Factors which affect stability Excipient Sodium edetate Induces Degradation
AerosolIpratropium bromide Antimuscarinic
AerosolSalbutamol sulfate Beta-stimulant
Stability of mixtures
Glass NaCl 0.9%  
 25°C Light
Aerosol Ipratropium bromide Liquid Atrovent® 11 µg/ml
Aerosol Salbutamol sulfate Liquid Sultanol® 55 µg/ml
5 Hour
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