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References   References 2720  
Type : Journal
Research teams : Berlin - Free University of Berlin, Institute of Pharmacy
Authors : Buech G, Bertelmann E, Pleyer U, Siebenbrodt I, Borchert HH.
Title : Formulation of sirolimus eye drops corneal permeation studies.
Reference : J Ocular Pharm Ther ; 23, 3: 292-303. 2007
Level of Evidence : 
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
List of drugs
Eye-dropsSirolimus Immunosuppressant
Stability in solutions Not specified powder 10 mg
®=? (LC Laboratories (Woburn, MA))
triacetin 2 g
Synperonic F64® 1,5 g
propylene glycol 4 g
Distilled water 2,5 g
25° C Protect from light
365 Day
  Mentions Légales