| Type : |
Journal |
|
| Research teams : |
Hobart - University of Tasmania, School of Pharmacy |
| Authors : |
Peterson GM, Meaney MF, Reid CA. |
| Title : |
Stability of extemporaneously prepared mixtures of metoprolol and spironolactone. |
| Reference : |
Aust J Hosp Pharm ; 19,: 344-346. 1989 |
|
| Level of Evidence : |
|
| Physical stability : |
|
| Chemical stability : |
|
| Other methods : |
|
| Comments : |
|
List of drugs
 Metoprolol tartrate
|
 |
 |
 |
 |
1000 mg
Betaloc® |
| Tragacanth powder |
3000 mg |
| chloroform water |
2.5 ml |
| Simple syrup |
12.5 ml |
| Distilled water |
>> 100 ml |
|
21-25°C |
 |
| 90 |
 |
|
|
|
|
|
1000 mg
Betaloc® |
| Tragacanth powder |
3000 mg |
| chloroform water |
2.5 ml |
| Simple syrup |
12.5 ml |
| Distilled water |
>> 100 ml |
|
5-7°C |
|
| 90 |
|
|
|
|
|
Spironolactone
|
 |
|
|
|
500 mg
Aldactone® |
| Tragacanth powder |
1500 mg |
| Glycerin |
2.5 ml |
| Benzoic acid |
? |
| chloroform water |
1.25 ml |
| Simple syrup |
20 ml |
| Distilled water |
>> 100 ml |
|
21-25°C |
|
| 28 |
|
|
|
|
|
|
500 mg
Aldactone® |
| Tragacanth powder |
1500 mg |
| Glycerin |
2.5 ml |
| Benzoic acid |
? |
| chloroform water |
1.25 ml |
| Simple syrup |
20 ml |
| Distilled water |
>> 100 ml |
|
5-7°C |
|
| 62 |
|
|
|
|
|
