Last update :
19/11/2024
References   References 252  
Type : Journal

Research teams : Round Lake - Baxter Healthcare Corporation
Authors : Koberda M, Zieske PA, Raghavan NV, Payton RJ.
Title : Stability of bleomycin sulfate reconstituted in 5% dextrose injection or 0.9% sodium chloride injection stored in glass vials or polyvinyl chloride containers.
Reference : Am J Hosp Pharm ; 47: 2528-2529. 1990

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products detected but not quantified
No visual inspection

List of drugs
injectionBleomycin sulfate Anticancer drug
Factors which affect stability Solvent Glucose 5% Induces Degradation
Stability in solutions Glass Sodium chloride 0,9% 0,3 & 3 mg/ml 22°C-25°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,3 & 3 mg/ml 22°C-25°C Not specified
24 Hour
Incompatible + Glucose 5%

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