Last update :
03/05/2024
References   References 2505  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/44/10/2287

Research teams : Groton - Pfizer Inc
Authors : Ahmed I, Day P.
Title : Stability of cefazolin sodium in various artificial tear solutions and aqueous vehicles
Reference : Am J Hosp Pharm ; 44: 2287-2290 1987

Level of Evidence : 
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 

List of drugs
Eye-dropsCefazolin sodium Antibiotic
Factors which affect stability Temperature 25°C Induces Degradation
Factors which affect stability PH PH >7 Induces Degradation
Stability in solutions Glass Medicine bottle for injection 16,6 mg
Kefzol® (Eli Lilly)
NaCl 0.9% >> 5 ml
4°C Protect from light
7 Day
Stability in solutions Glass Medicine bottle for injection 16,6 mg
Kefzol® (Eli Lilly)
Acetate buffer pH 4.5 >> 5 ml
4°C Protect from light
7 Day
Stability in solutions Glass Medicine bottle for injection 16,6 mg
Kefzol® (Eli Lilly)
Acetate buffer pH 5.7 >> 5 ml
4°C Protect from light
7 Day

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