Last update :
28/04/2024
References   References 2437  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/6/659

Research teams : Minneapolis - University of Minnesotta, College of Pharmacy
Authors : Larson TA, Uden DL, Schilling CG.
Title : Stability of epinephrine hydrochloride in an extemporaneously compounded topical anesthetic solution of lidocaine, racepinephrine, and tetracaine
Reference : Am J Health-Syst Pharm ; 53: 659-662. 1996

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
OintmentsEpinephrine hydrochloride Sympathomimetic
OintmentsLidocaine hydrochloride Local anesthetic
OintmentsTetracain hydrochloride Local anesthetic
Stability of mixtures
Glass 4°C Protect from light
Ointments Lidocaine hydrochloride Medicine bottle for injection ® = ? (Abbott Laboratories) 20 % 10
Ointments Epinephrine hydrochloride Medicine bottle for injection ® = (Nephron) 2,25% 5
Ointments Tetracain hydrochloride Medicine bottle for injection ® = ? (Winthrop Laboratories) 2% 12,5
182 Day

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