Last update :
29/10/2024
References   References 2426  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/5/549

Research teams : Rochester - University of Rochester Medical Center, Department of Pharmacy
Authors : Anaizi NH, Swenson CF, Dentinger PJ.
Title : Stability of acetylcysteine in an extemporaneously compounded ophthalmic solution
Reference : Am J Health-Syst Pharm ; 54: 549-553. 1997

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
Eye-dropsN-acetylcysteine Various
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Polyethylene Medicine bottle for injection 1500mg=7.5ml
Mucosil®
Chlorobutanol 37.5ml
Liquidfilm Tears® 7.5ml
2-8°C Not specified
35 Day
Stability in solutions Polyethylene Medicine bottle for injection 1500mg=7.5ml
Mucosil®
Chlorobutanol 37.5ml
Liquidfilm Tears® 7.5ml
23-25°C Not specified
30 Day

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