Last update :
19/11/2024
References   References 2336  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/439.

Research teams : Vancouver - Children\'s and Women\'s Health Center of British Columbia
Authors : Ensom M.H.H, Decarie D, Leung K, MontgomeryC
Title : Stability of Hydromorphone–Ketamine Solutions in Glass Bottles, Plastic Syringes, and IV Bags for Pediatric Use
Reference : Can J Hosp Pharm ; 62, 2: 112-118. 2009

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionHydromorphone hydrochloride Analgesic
Compatible 0.2 mg/ml + injectionKetamine hydrochloride 0.2 >> 1 mg/ml + Sodium chloride 0,9%
injectionKetamine hydrochloride General anesthetic
Compatible 0.2 >> 1 mg/ml + injectionHydromorphone hydrochloride 0.2 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Protect from light
injection Hydromorphone hydrochloride 0,2 mg/ml
injection Ketamine hydrochloride 0,2 >> 1 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 25°C Protect from light
injection Hydromorphone hydrochloride 0,2 mg/ml
injection Ketamine hydrochloride 0,2 >> 1 mg/ml
7 Day
Polypropylen Syringe Sodium chloride 0,9% 25°C Protect from light
injection Ketamine hydrochloride 0,2 >> 1 mg/ml
injection Hydromorphone hydrochloride 0,2 mg/ml
7 Day

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