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References   References 2308  
Type : Journal
Research teams : Stockport - Stepping Hill Hospital, Quality Control North Wes
Authors : Hudson S.J, Jones M.F, Nolan S, Ellis H, Duncombe R, Alexander-Williams J.M.
Title : Stability of premixed syringes of diamorphine and hyperbaric bupivacaine.
Reference : Int J Obstet Anesth ; 14, 4: 284-287. 2005
Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection
List of drugs
injectionBupivacaine hydrochloride Local anesthetic
Compatible 4 mg/ml + injectionDiamorphine hydrochloride 0,1 mg/ml + Glucose 8%
injectionDiamorphine hydrochloride Analgesic
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability pH 4 < pH < 5 Induces Enhanced stability
Compatible 0,1 mg/ml + injectionBupivacaine hydrochloride 4 mg/ml + Glucose 8%
Stability of mixtures
Polypropylen Syringe Glucose 8% 7°C Not specified
injection Bupivacaine hydrochloride 4 mg/ml
injection Diamorphine hydrochloride 0,1 mg/ml
26 Day
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