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References   References 23  
Type : Journal
Research teams : Liège - University of Liège, School of Pharmacy
Authors : Evrard B, Ceccato A, Gaspard O, Delattre L, Delporte JP.
Title : Stability of ondansetron hydrochloride and dexamethasone sodium phosphate in 0.9% sodium chloride and in 5% dextrose injection.
Reference : Am J Health-Syst Pharm ; 54: 1065-1068. 1997
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0,22 >> 0,43 mg/ml + InjectionOndansetron hydrochloride 0,14 >> 0,76 mg/ml + NaCl 0,9% or Glucose 5%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0,14 >> 0,76 mg/ml + InjectionDexamethasone sodium phosphate 0,22 >> 0,43 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 15-25°C Protect from light
Injection Ondansetron hydrochloride 0,15 mg/ml
Injection Dexamethasone sodium phosphate 0,43 mg/ml
28 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 2-8°C Protect from light
Injection Ondansetron hydrochloride 0,15 mg/ml
Injection Dexamethasone sodium phosphate 0,43 mg/ml
28 Day
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