Last update :
28/04/2024
References   References 2280  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2828

Research teams : San Francisco - Elan Pharmaceuticals Inc
Authors : Shields DE, Aclan J, Szatkowski A.
Title : Chemical stability of admixtures combining ziconotide with fentanyl or sufentanil during simulated intrathecal administration.
Reference : Int J Pharm Compound ; 12, 5: 463-466. 2008

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Stability indicating capability inadequately assessed

List of drugs
InjectionFentanyl citrate Analgesic
InjectionSufentanil citrate Analgesic
InjectionZiconotide acetate Analgesic
Stability of mixtures
Not specified Sodium chloride 0,9% 37°C Protect from light
Injection Ziconotide acetate 25 µg/ml
Injection Fentanyl citrate 1 µg/ml
26 Day
Not specified Sodium chloride 0,9% 37°C Protect from light
Injection Ziconotide acetate 25 µg/ml
Injection Sufentanil citrate 1 mg/ml
33 Day

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