Last update :
19/11/2024
References   References 2270  
Type : Journal
Web link : https://doi.org/10.1345/aph.1L079

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Kupiec TC, Aloumanis V, Ben M, Trissel LA, Chan P, Patterson J.
Title : Physical and chemical stability of esomeprazole sodium solutions.
Reference : Ann Pharmacotherapy ; 42, 9: 1247-1251. 2008

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionEsomeprazole sodium Proton pump inhibitor
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 mg/ml 23°C Not specified
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 mg/ml 4°C Not specified
5 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,8 mg/ml 23°C Not specified
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,8 mg/ml 4°C Not specified
5 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0,4 mg/ml 23°C Not specified
48 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0,4 mg/ml 4°C Not specified
5 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0,8 mg/ml 23°C Not specified
48 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0,8 mg/ml 4°C Not specified
5 Day

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