Last update :
27/11/2024
References   References 2227  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2736

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trusley C, Ben M, Kupiec TC, Trissel LA.
Title : Compatibility and stability of palonosetron hydrochloride with four neuromuscular blocking agents during simulated Y-site administration.
Reference : Int J Pharm Compound ; 12, 2: 156-160. 2008

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionCisatracurium besylate Curarimimetic
Compatible 0,5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionCisatracurium besylate 0,5 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionRocuronium bromide 1 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionSuxamethonium chloride 2 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionVecuronium bromide 1 mg/ml + Glucose 5%
injectionRocuronium bromide Curarimimetic
Compatible 1 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionSuxamethonium chloride Curarimimetic
Compatible 2 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionVecuronium bromide Curarimimetic
Compatible 1 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Not specified
injection Cisatracurium besylate 0.26 mg/ml
injection Palonosetron hydrochloride 25.4 µg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Rocuronium bromide 0.5 mg/ml
injection Palonosetron hydrochloride 25 µg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 26 µg/ml
injection Suxamethonium chloride 1.05 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Palonosetron hydrochloride 25.6 µg/ml
injection Vecuronium bromide 0.5 mg/ml
4 Hour

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