Last update :
19/11/2024
References   References 2205  
Type : Journal
Web link : http://www.unboundmedicine.com/medline/ebm/record/17225568/abstract/Compatibiliity_and_stability_of_furosemide_and_dexamethasone_combined_in_infusion_solutions

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Negro S, Rendon AL, Azuara ML, S?nchez Y, Fern?ndez-Carballido A, Barcia E.
Title : Compatibility and stability of furosemide and dexamethasone combined in infusion solutions.
Reference : Arzneimittel Forschung ; 56, 10: 714-720. 2006

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
No comments for the degradation products
Changes in pH not commented or difficult to interpret
Unencrypted results (eg graphic)

List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.33>>3.33 mg/ml + injectionFurosemide 3.33>>10 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Compatible 3.33>>10 mg/ml + injectionDexamethasone sodium phosphate 0.33>>3.33 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
injection Furosemide 3.33>>10 mg/ml
injection Dexamethasone sodium phosphate 0.33>>3.33 mg/ml
5 Day
Polypropylene Sodium chloride 0,9% 5°C Protect from light
injection Furosemide 3.33>>10 mg/ml
injection Dexamethasone sodium phosphate 0.33>>3.33 mg/ml
5 Day

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