Last update :
03/05/2024
References   References 2203  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/13/2/119

Research teams : Plymouth - Derriford Hospital,Department of Pharmacy
Authors : Kaestner S, Sewell G.
Title : A sequential temperature cycling study for the investigation of carboplatin infusion stability to facilitate 'dose-banding'.
Reference : J Oncol Pharm Practice ; 13: 119-126. 2007

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Mass balance 
Comments : 
Degradation products identified

List of drugs
InjectionCarboplatin Anticancer drug
Stability in solutions Polyvinyl chloride Glucose 5% 2.15 mg/ml 4°C Protect from light
84 Day
Stability in solutions Polyolefine Glucose 5% 0.7 & 2.15 mg/ml 4°C Protect from light
84 Day

  Mentions Légales