Last update :
19/11/2024
References   References 2175  
Type : Journal
Web link : http://www.john-libbey-eurotext.fr/en/revues/bio_rech/jpc/e-docs/00/04/1E/A8/resume.md?type=text.html

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Dalle M, Sautou-Miranda V, Balayssac D, Bourlon S, Bagel S, Chopineau J.
Title : Peut-on conditionner les solutions de docétaxel dans des poches en PVC ?
Reference : J Pharm Clin ; 25, 3: 147-152. 2006

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Search of DEHP 
Comments : 
No comments for the degradation products

List of drugs
injectionDocetaxel Anticancer drug
Factors which affect stability Container Polyvinyl chloride Induces Leaching
Factors which affect stability Temperature Increase Induces Reduced stability
Stability in solutions Polyethylene Sodium chloride 0,9% 0.74 mg/ml 23°C Protect from light
8 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0.74 mg/ml 6°C Protect from light
48 Hour

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