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References   References 2174  
Type : Journal
Web link : http://archive.eahp.eu/EJHP-Science-archive/Issue-6-2006
Research teams : Bath - Department of Pharmacy & Pharmacology
Authors : Kattige A.
Title : Long-term physical and chemical stability of a generic paclitaxel infusion under simulated storage and clinical-use conditions.
Reference : EJHP Science ; 12, 6: 129-134. 2006
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Mass balance 
Comments : 
Degradation products not observed in real conditions
List of drugs
InjectionPaclitaxel Anticancer drug
Factors which affect stability Concentration Increase Induces Precipitation
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,3 mg/ml 5°C Protect from light
28 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,75 mg/ml 5°C Protect from light
16 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 1,2 mg/ml 25°C Protect from light
4 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 1,2 mg/ml 5°C Protect from light
12 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,3 & 0,75 mg/ml 25°C Protect from light
6 Day
Stability in solutions Polyolefine Glucose 5% 0,3 mg/ml 25°C Protect from light
8 Day
Stability in solutions Polyolefine Glucose 5% 0,75 mg/ml 25°C Protect from light
4 Day
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