Last update :
28/04/2024
References   References 2172  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/12/4/211

Research teams : Plymouth - Derriford Hospital,Department of Pharmacy
Authors : Donyai P, Sewell GJ.
Title : Physical and chemical stability of paclitaxel infusions in different container types.
Reference : J Oncol Pharm Practice ; 12, 4: 211-222. 2006

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Mass balance 
Comments : 
No comments for the degradation products

List of drugs
InjectionPaclitaxel Anticancer drug
Factors which affect stability Temperature Increase Induces Reduced stability
Factors which affect stability Concentration Increase Induces Reduced stability
Stability in solutions Glass Sodium chloride 0,9% 0.3 mg/ml 2-8°C Protect from light
13 Day
Stability in solutions Glass Sodium chloride 0,9% 0.3 mg/ml 25°C Protect from light
3 Day
Stability in solutions Glass Sodium chloride 0,9% 1.2 mg/ml 2-8°C Protect from light
8 Day
Stability in solutions Glass Sodium chloride 0,9% 1.2 mg/ml 25°C Protect from light
5 Day
Stability in solutions Glass Glucose 5% 0.3 mg/ml 2-8°C Protect from light
20 Day
Stability in solutions Glass Glucose 5% 0.3 & 1.2 mg/ml 25°C Protect from light
7 Day
Stability in solutions Glass Glucose 5% 1.2 mg/ml 2-8°C Protect from light
8 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0.3 mg/ml 2-8°C Protect from light
13 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0.3 & 1.2 mg/ml 25°C Protect from light
3 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 1.2 mg/ml 2-8°C Protect from light
9 Day
Stability in solutions Polyethylene Glucose 5% 0.3 mg/ml 2-8°C Protect from light
13 Day
Stability in solutions Polyethylene Glucose 5% 0.3 & 1.2 mg/ml 25°C Protect from light
3 Day
Stability in solutions Polyethylene Glucose 5% 1.2 mg/ml 2-8°C Protect from light
10 Day

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