Last update :
14/12/2024
References   References 2132  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4025

Research teams : Salt Lake City - Primary children\'s hospital, department of Pharmacy
Authors : Anderson Collin R, Halford Zachery, MacKay Mark.
Title : Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes.
Reference : Int J Pharm Compound ; 19, 4 : 344-347. 2015

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
injectionDiphenhydramine hydrochloride Antihistamine (H1)
injectionLorazepam Anxiolytic
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Light
injection Dexamethasone sodium phosphate 0.27 mg/ml
injection Lorazepam 0.16 mg/ml
injection Diphenhydramine hydrochloride 4 mg/ml
48 Hour

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