Last update :
27/11/2024
References   References 2122  
Type : Journal
Web link : http://archive.eahp.eu/EJHP-Science-archive/Issue-4-2006

Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Kambia NK, Luyckx M, Dine T, Dupin-Sriet T, Gressier B, Brunet C.
Title : Stability and compatibility of paracetamol injection admixed with ketoprofen.
Reference : EJHP Science ; 12, 4: 81-84. 2006

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
injectionKetoprofene Anti-inflammatory
Compatible 1 mg/ml + injectionParacetamol 10 mg/ml + None
injectionParacetamol Analgesic
Compatible 10 mg/ml + injectionKetoprofene 1 mg/ml + None
Stability of mixtures
Glass None 20-25°C Not specified
injection Ketoprofene 1 mg/ml
injection Paracetamol 10 mg/ml
48 Hour

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