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References   References 211  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/48/6/1237
Research teams : Atlanta - Mercer University, Southern School of Pharmacy
Authors : Strom JG, Miller SW.
Title : Stability and compatibility of methylprednisolone sodium succinate and cimetidine hydrochloride in 5% dextrose injection.
Reference : Am J Hosp Pharm ; 48: 1237-1241. 1991
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 3 mg/ml + InjectionHydrocortisone sodium succinate 0.4 & 1.25 mg/ml + Glucose 5%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 0.4 & 1.25 mg/ml + InjectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Stability of mixtures
Polyvinyl chloride Glucose 5% 24°C Not specified
Injection Cimetidine hydrochloride 3 mg/ml
Injection Methylprednisolone sodium succinate 0,4 & 1,25 mg/ml
24 Hour
  Mentions Légales