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References   References 2107  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2394
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Zhang Y, Xu QA.
Title : Physical and chemical stability of palonosetron hydrochloride with dacarbazine and with methylprednisolone sodium succinate during simulated Y-site administration.
Reference : Int J Pharm Compound ; 10: 234-236. 2006
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionDacarbazine Anticancer drug
Compatible 4 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionDacarbazine 4 mg/ml + Glucose 5%
Incompatible 50 µg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Light
injection Palonosetron hydrochloride 25 µg/ml
injection Dacarbazine 0,05 mg/ml
4 Hour
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