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References   References 210  
Type : Journal
Research teams : Athens - University of Georgia, College of Pharmacy
Authors : Stewart JT, Warren FW, King AD.
Title : Stability of ranitidine hydrochloride and seven medications.
Reference : Am J Hosp Pharm ; 51: 1802-1807. 1994
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionAminophylline Various
Compatible 0.5 & 2 mg/ml + injectionRanitidine hydrochloride 0.05 & 2 mg/ml + NaCl 0,9% or Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 0.25 & 1 mg/ml + injectionRanitidine hydrochloride 0.05 & 2 mg/ml + NaCl 0,9% or Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 0.4 & 3.2 mg/ml + injectionRanitidine hydrochloride 0.05 & 2 mg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 1 & 8 mg/ml + injectionRanitidine hydrochloride 0.05 & 2 mg/ml + NaCl 0,9% or Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0.04 & 2 mg/ml + injectionRanitidine hydrochloride 0.05 & 2 mg/ml + NaCl 0,9% or Glucose 5%
injectionNitroprusside sodium Vasodilator
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.004 & 0.008 mg/ml + injectionRanitidine hydrochloride 0.05 & 2 mg/ml + NaCl 0,9% or Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.05 & 2 mg/ml + injectionAminophylline 0.5 & 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.05 & 2 mg/ml + injectionDobutamine hydrochloride 0.25 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.05 & 2 mg/ml + injectionDopamine hydrochloride 0.4 & 3.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.05 & 2 mg/ml + injectionLidocaine hydrochloride 1 & 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.05 & 2 mg/ml + injectionMethylprednisolone sodium succinate 0.04 & 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.05 & 2 mg/ml + injectionNorepinephrine bitartrate 0.004 & 0.008 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Aminophylline 0,5 & 2 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Lidocaine hydrochloride 1 & 8 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Dobutamine hydrochloride 0,25 & 1 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Nitroprusside sodium 0,05 & 0,4 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Dopamine hydrochloride 0,4 & 3,2 mg/ml
48 Hour
Polyvinyl chloride Sodium chloride 0,9% ? Not specified
injection Ranitidine hydrochloride 0,05 mg/ml
injection Methylprednisolone sodium succinate 0,04 mg/ml
24 Hour
Polyvinyl chloride Sodium chloride 0,9% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Methylprednisolone sodium succinate 2 mg/ml
24 Hour
Polyvinyl chloride Sodium chloride 0,9% ? Not specified
injection Ranitidine hydrochloride 2 mg/ml
injection Methylprednisolone sodium succinate 0,04 mg/ml
48 Hour
Polyvinyl chloride Glucose 5% ? Not specified
injection Ranitidine hydrochloride 2 mg/ml
injection Norepinephrine bitartrate 0,004 mg/ml
4 Hour
Polyvinyl chloride Glucose 5% ? Not specified
injection Ranitidine hydrochloride 2 mg/ml
injection Norepinephrine bitartrate 0,008 mg/ml
12 Hour
Polyvinyl chloride Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 mg/ml
injection Norepinephrine bitartrate 0,004 & 0,008 mg/ml
48 Hour
Polyvinyl chloride Glucose 5% ? Not specified
injection Ranitidine hydrochloride 0,05 & 2 mg/ml
injection Methylprednisolone sodium succinate 0,04 & 2 mg/ml
48 Hour
  Mentions Légales