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References   References 2094  
Type : Journal
Web link : http://archive.eahp.eu/EJHP-Science-archive/Issue-1-2006
Research teams : Fribourg - University Hospital Freiburg, Department of Pharmacy
Authors : Trittler R.
Title : Stability of intravenous admixtures of doxorubicin and vincristine confirmed by LC-MS.
Reference : EJHP Science ; 12, 1: 10-12. 2006
Level of Evidence : 
Level of evidence A
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
High Performance Liquid Chromatography - fluorescence detector
Other methods : 
Comments : 
Degradation products detected but not quantified
List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
InjectionVincristine sulfate Anticancer drug
Stability of mixtures
Polyolefine Sodium chloride 0,9% 25°C Not specified
Injection Doxorubicin hydrochloride 1,4 mg/ml
Injection Vincristine sulfate 0,033 & 0,053 mg/ml
4 Day
Polyolefine Sodium chloride 0,9% 8°C Not specified
Injection Doxorubicin hydrochloride 1,4 mg/ml
Injection Vincristine sulfate 0,033 & 0,053 mg/ml
14 Day
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