Last update :
29/10/2024
References   References 208  
Type : Journal

Research teams : Tucson - University of Arizona, Department of Pharmacy Practice & Science
Authors : Nolan PE, Hoyer GL, Ledoux JH, Fox JL.
Title : Stability of ranitidine hydrochloride and human insulin in 0.9% sodium chloride injection.
Reference : Am J Health-Syst Pharm ; 54: 1304-1306. 1997

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionInsulin Glucose-lowering
Factors which affect stability Container Polyvinyl chloride Induces Adsorption
injectionRanitidine hydrochloride Antihistamine (H2)
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 25°C Light
injection Ranitidine hydrochloride 1 mg/ml
injection Insulin 1 UI/ml
1 Hour

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