Last update :
19/11/2024
References   References 2051  
Type : Journal

Research teams : Stockport - Stepping Hill Hospital, Quality Control North Wes
Authors : Sanchez del Aguila MJ, Jones MF, Vohra A.
Title : Premixed solutions of diamorphine in ropivacaine for epidural anaesthesia: a study on long-term stability.
Reference : Br J Anaesth ; 90: 179-182. 2003

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection
Stability indicating capability inadequately assessed

List of drugs
injectionDiamorphine hydrochloride Analgesic
Factors which affect stability Storage Light Induces Degradation
Factors which affect stability Temperature Increase Induces Degradation
injectionRopivacain hydrochloride Local anesthetic
Stability of mixtures
Polypropylene None 21°C Not specified
injection Ropivacain hydrochloride 1 mg/ml
injection Diamorphine hydrochloride 0,045 mg/ml
16 Day
Polypropylene None 40°C Not specified
injection Ropivacain hydrochloride 1 mg/ml
injection Diamorphine hydrochloride 0,045 mg/ml
6 Day
Polypropylene None 4°C Not specified
injection Ropivacain hydrochloride 1 mg/ml
injection Diamorphine hydrochloride 0,045 mg/ml
30 Day
Not specified None 21°C Not specified
injection Ropivacain hydrochloride 2 mg/ml
injection Diamorphine hydrochloride 0,025 mg/ml
28 Day
Not specified None 40°C Not specified
injection Ropivacain hydrochloride 2 mg/ml
injection Diamorphine hydrochloride 0,025 mg/ml
6 Day
Not specified None 4°C Not specified
injection Ropivacain hydrochloride 2 mg/ml
injection Diamorphine hydrochloride 0,025 mg/ml
70 Day

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