Last update :
28/04/2024
References   References 2020  
Type : Journal
Web link : http://www.cshp.ca/dms/dmsView/1_abstract-april05-A1.pdf

Research teams : Paris - University Hospital Pitié-Salpétrière,Department of pharmacy
Authors : Blondeel S, Pelloquin A, Pointereau-Bellanger A, Thuillier A, Fernandez C.
Title : Effect of freezing on stability of a fortified 5 mg/ml ticarcillin ophtalmic solution.
Reference : Can J Hosp Pharm ; 58: 65-70. 2005

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
Eye-dropsTicarcillin sodium Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Glass Medicine bottle for injection 50 mg
Ticarpen®
NaCl 0.9% >> 10 ml
-20°C Protect from light
63 Day
Stability in solutions Glass Medicine bottle for injection 50 mg
Ticarpen®
NaCl 0.9% >> 10 ml
25°C With or without light
3 Day
Stability in solutions Glass Medicine bottle for injection 50 mg
Ticarpen®
NaCl 0.9% >> 10 ml
4°C Not specified
7 Day

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