Last update :
29/10/2024
References   References 2010  
Type : Journal
Web link : https://doi.org/10.1345/aph.1E620

Research teams : Bondy - University Hospital Jean Verdier, Department of Pharmacy
Authors : André P, Cisternino S, Chiadmi F, Toledano A, Schlatter J, Fain O, Fontan JE.
Title : Stability of bortezomib 1 mg/ml solution in plastic syringe and glass vial.
Reference : Ann Pharmacotherapy ; 39: 1462-1466. 2005

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products quantified but not identified

List of drugs
injectionBortezomib Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 5°C Protect from light
5 Day
conflicting data
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 22°C Light
3 Day
conflicting data
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 5°C Protect from light
5 Day
conflicting data

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