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References   References 1966  
Type : Journal
Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Barcia E, Reyes R, Azuara L, Sànchez Y, Negro S.
Title : Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide.
Reference : Support Care Cancer ; 13, 4: 239-245. 2005
Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Water loss by evaporation PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
InjectionMorphine hydrochloride Analgesic
Compatible 1.67 >> 10 mg/ml + InjectionScopolamine N-butyl bromide 3.33 >> 6.67 mg/ml + Sodium chloride 0,9%
InjectionScopolamine N-butyl bromide Antimuscarinic
Compatible 3.33 >> 6.67 mg/ml + InjectionMorphine hydrochloride 1.67 >> 10 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
Injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
Injection Morphine hydrochloride 1,67>> 10 mg/ml
15 Day
Polypropylene Sodium chloride 0,9% 4°C Protect from light
Injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
Injection Morphine hydrochloride 1,67>> 10 mg/ml
15 Day
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