Last update :
19/11/2024
References   References 1966  
Type : Journal

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Barcia E, Reyes R, Azuara L, Sànchez Y, Negro S.
Title : Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide.
Reference : Support Care Cancer ; 13, 4: 239-245. 2005

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Water loss by evaporation PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionMorphine hydrochloride Analgesic
Compatible 1.67 >> 10 mg/ml + injectionScopolamine N-butyl bromide 3.33 >> 6.67 mg/ml + Sodium chloride 0,9%
injectionScopolamine N-butyl bromide Antimuscarinic
Compatible 3.33 >> 6.67 mg/ml + injectionMorphine hydrochloride 1.67 >> 10 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
injection Morphine hydrochloride 1,67>> 10 mg/ml
15 Day
Polypropylene Sodium chloride 0,9% 4°C Protect from light
injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
injection Morphine hydrochloride 1,67>> 10 mg/ml
15 Day

  Mentions Légales