Last update :
19/11/2024
References   References 1897  
Type : Journal
Web link : http://www.eahponline.org/asp/practice_overview_archive.asp?m=4&s=1&year=2001&nr=3

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Sautou-Miranda V, Brigas F, Thibault M, Chopineau J.
Title : Compatibility of doxorubicin, daunorubicin and epirubicin with low-density polyethylene and polyvinyl chloride, and stability in various conditions of storage.
Reference : EJHP ; 7, 3: 108-115. 2001

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
injectionDaunorubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,02 mg/ml 22°C Light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 22°C Protect from light
8 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
8 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 22°C Light
48 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,1 mg/ml 22°C Light
8 Day
injectionDoxorubicin hydrochloride Anticancer drug
Factors which affect stability Concentration Reduction Induces Reduced stability
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 22°C Not specified
8 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
8 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0,02 mg/ml 22°C Light
24 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,02 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyethylene Glucose 5% 0,02 mg/ml 22°C Protect from light
8 Day
Stability in solutions Polyethylene Glucose 5% 0,02 mg/ml 4°C Protect from light
8 Day
injectionEpirubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 22°C Protect from light
8 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
8 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,02 mg/ml 22°C Light
96 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,1 mg/ml 22°C Protect from light
8 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
8 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0,02 mg/ml 22°C Light
24 Hour
Stability in solutions Polyethylene Glucose 5% 0,02 mg/ml 22°C Light
96 Hour

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