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References   References 1885  
Type : Journal
Web link : http://springerlink.metapress.com/content/j31267w1j163v4xu/?p=39e9e6d7b8c646288241e2571f71b109&pi=8
Research teams : Nijmegen - University Hospital Nijmegen St Radboud, Department of Clinical Pharmacy
Authors : Essink-Tjebbes CM, Burger DM, Beelen, Wuis EW, Heckster YA.
Title : Long-term stability of morphine and bupivacaine mixture for spinal use.
Reference : Pharm World Sci ; 21: 144-146. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionBupivacaine hydrochloride Local anesthetic
Compatible 7,5 mg/ml + injectionMorphine hydrochloride 0,2 mg/ml + Sodium chloride 0,9%
injectionMorphine hydrochloride Analgesic
Compatible 0,2 mg/ml + injectionBupivacaine hydrochloride 7,5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 20°C-25°C Light
injection Morphine hydrochloride 0,2 mg/ml
injection Bupivacaine hydrochloride 7,5 mg/ml
540 Day
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