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References   References 187  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/50/9/1907
Research teams : Little Rock - University of Arkansas Medical Center, College of Pharmacy
Authors : Olsen KM, Gurley BJ, Davis GA, Christensen R, Monaghan MS.
Title : Stability of flumazenil with selected drugs in 5% dextrose injection.
Reference : Am J Hosp Pharm ; 50: 1907-1912. 1993
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionAminophylline Various
Compatible 2 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 2,4 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 2 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionFamotidine Antihistamine (H2)
Compatible 0,08 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionFlumazenil Antidote
Compatible 0,02 mg/ml + InjectionAminophylline 2 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionCimetidine hydrochloride 2,4 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionDopamine hydrochloride 3,2 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionFamotidine 0,08 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionHeparin sodium 50 UI/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionLidocaine hydrochloride 4 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionProcainamide hydrochloride 4 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + InjectionRanitidine hydrochloride 0,3 mg/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 50 UI/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionLidocaine hydrochloride Local anesthetic
Compatible 4 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionProcainamide hydrochloride Anti-arrhythmic
Compatible 4 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0,3 mg/ml + InjectionFlumazenil 0,02 mg/ml + Glucose 5%
Stability of mixtures
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Dopamine hydrochloride 3,2 mg/ml
12 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Aminophylline 2 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Dobutamine hydrochloride 2 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Cimetidine hydrochloride 2,4 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Famotidine 0,08 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Ranitidine hydrochloride 0,3 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Heparin sodium 50 UI/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Lidocaine hydrochloride 4 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
Injection Flumazenil 0,02 mg/ml
Injection Procainamide hydrochloride 4 mg/ml
24 Hour
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