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References   References 187  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/50/9/1907
Research teams : Little Rock - University of Arkansas Medical Center, College of Pharmacy
Authors : Olsen KM, Gurley BJ, Davis GA, Christensen R, Monaghan MS.
Title : Stability of flumazenil with selected drugs in 5% dextrose injection.
Reference : Am J Hosp Pharm ; 50: 1907-1912. 1993
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionAminophylline Various
Compatible 2 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 2,4 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 2 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionFamotidine Antihistamine (H2)
Compatible 0,08 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionFlumazenil Antidote
Compatible 0,02 mg/ml + injectionAminophylline 2 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionCimetidine hydrochloride 2,4 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionDopamine hydrochloride 3,2 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionFamotidine 0,08 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionHeparin sodium 50 UI/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionLidocaine hydrochloride 4 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionProcainamide hydrochloride 4 mg/ml + Glucose 5%
Compatible 0,02 mg/ml + injectionRanitidine hydrochloride 0,3 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 50 UI/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 4 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionProcainamide hydrochloride Anti-arrhythmic
Compatible 4 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0,3 mg/ml + injectionFlumazenil 0,02 mg/ml + Glucose 5%
Stability of mixtures
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Dopamine hydrochloride 3,2 mg/ml
12 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Aminophylline 2 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Dobutamine hydrochloride 2 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Cimetidine hydrochloride 2,4 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Famotidine 0,08 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Ranitidine hydrochloride 0,3 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Heparin sodium 50 UI/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Lidocaine hydrochloride 4 mg/ml
24 Hour
Polyvinyl chloride Glucose 5% 23°C Light
injection Flumazenil 0,02 mg/ml
injection Procainamide hydrochloride 4 mg/ml
24 Hour
  Mentions Légales