Last update :
19/11/2024
References   References 1868  
Type : Journal

Research teams : Saint Germain en Laye - CHI Poissy Saint Germain en Laye - Service Pharmacie
Authors : Husson E, Crauste-Manciet S, Hadj-Salah E, ,Segier JC, Broissard D.
Title : Stabilité galénique de mélanges commercialisés de nutrition parentérale en présence de médicaments: médicaments dans le mélange.
Reference : Nutr Clin Metab ; 17: 8-14. 2003

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 1.096 >> 1.5 mg/ml + Parenteral nutrition (with lipids)
injectionAmikacin sulfate Antibiotic
Compatible 0.487 >> 0.667 mg/ml + Parenteral nutrition (with lipids)
injectionHeparin sodium Anticoagulant
Compatible 20,458 >> 28,000 UI/ml + Parenteral nutrition (with lipids)
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0.058 >> 0.080 mg/ml + Parenteral nutrition (with lipids)
injectionOndansetron hydrochloride Antiemetic
Compatible 0.016 & 0.021 mg/ml + Parenteral nutrition (with lipids)
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.049 >> 0.067 mg/ml + Parenteral nutrition (with lipids)
injectionVancomycin hydrochloride Antibiotic
Compatible 0.0974 >> 1.333 mg/ml + Parenteral nutrition (with lipids)

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