Last update :
03/05/2024
References   References 1859  
Type : Journal

Research teams : L'aquila - University of L'Aquila
Authors : Anacardio R, Perilli O, Pagnanelli F, Bartolini S, gentile MM, Mazzeo P, Carlucci G.
Title : Physicochemical compatibility between thiocolchicoside injections (Miotens®) and pharmaceutical products frequently used for combined therapy.
Reference : Il Farmaco ; 57: 925-930. 2002

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionAcetylsalicylic acid lysinate Analgesic
Compatible 142.86 mg/ml + InjectionThiocolchicoside 0.57 mg/ml + None
InjectionBetamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + InjectionThiocolchicoside 1 mg/ml + None
InjectionCyanocobalamine Vitamin
Compatible 1.25 mg/ml + InjectionThiocolchicoside 1 mg/ml + None
InjectionDiclofenac Anti-inflammatory
Compatible 15 mg/ml + InjectionThiocolchicoside 0.8 mg/ml + None
InjectionKetoprofene Anti-inflammatory
Compatible 25 & 40 mg/ml + InjectionThiocolchicoside 1 mg/ml + None
InjectionKetorolac tromethamine Anti-inflammatory
Compatible 10 mg/ml + InjectionThiocolchicoside 1.33 mg/ml + None
InjectionPiroxicam Anti-inflammatory
Compatible 6.67 mg/ml + InjectionThiocolchicoside 1.33 mg/ml + None
InjectionTenoxicam Anti-inflammatory
Compatible 5 mg/ml + InjectionThiocolchicoside 1 mg/ml + None
InjectionThiocolchicoside Various
Compatible 0.57 mg/ml + InjectionAcetylsalicylic acid lysinate 142.86 mg/ml + None
Compatible 1 mg/ml + InjectionBetamethasone sodium phosphate 1 mg/ml + None
Compatible 1 mg/ml + InjectionCyanocobalamine 1.25 mg/ml + None
Compatible 0.8 mg/ml + InjectionDiclofenac 15 mg/ml + None
Compatible 1 mg/ml + InjectionKetoprofene 25 & 40 mg/ml + None
Compatible 1.33 mg/ml + InjectionKetorolac tromethamine 10 mg/ml + None
Compatible 1.33 mg/ml + InjectionPiroxicam 6.67 mg/ml + None
Compatible 1 mg/ml + InjectionTenoxicam 5 mg/ml + None
Stability of mixtures
Glass None 25°C Light
Injection Piroxicam 6.6 mg/ml
Injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C Light
Injection Thiocolchicoside 1 mg/ml
Injection Tenoxicam 5.2 mg/ml
3 Hour
Glass None 25°C
Injection Ketoprofene 40 mg/ml
Injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
Injection Diclofenac 15 mg/ml
Injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
Injection Ketorolac tromethamine 10 mg/ml
Injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
Injection Acetylsalicylic acid lysinate 140 mg/ml
Injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
Injection Betamethasone sodium phosphate 1 mg/ml
Injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
Injection Thiocolchicoside 1 mg/ml
Injection Cyanocobalamine 1.25 mg/ml
3 Hour

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