Last update :
19/11/2024
References   References 1859  
Type : Journal

Research teams : L'aquila - University of L'Aquila
Authors : Anacardio R, Perilli O, Pagnanelli F, Bartolini S, gentile MM, Mazzeo P, Carlucci G.
Title : Physicochemical compatibility between thiocolchicoside injections (Miotens®) and pharmaceutical products frequently used for combined therapy.
Reference : Il Farmaco ; 57: 925-930. 2002

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionAcetylsalicylic acid lysinate Analgesic
Compatible 142.86 mg/ml + injectionThiocolchicoside 0.57 mg/ml + None
injectionBetamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + injectionThiocolchicoside 1 mg/ml + None
injectionCyanocobalamine Vitamin
Compatible 1.25 mg/ml + injectionThiocolchicoside 1 mg/ml + None
injectionDiclofenac Anti-inflammatory
Compatible 15 mg/ml + injectionThiocolchicoside 0.8 mg/ml + None
injectionKetoprofene Anti-inflammatory
Compatible 25 & 40 mg/ml + injectionThiocolchicoside 1 mg/ml + None
injectionKetorolac tromethamine Anti-inflammatory
Compatible 10 mg/ml + injectionThiocolchicoside 1.33 mg/ml + None
injectionPiroxicam Anti-inflammatory
Compatible 6.67 mg/ml + injectionThiocolchicoside 1.33 mg/ml + None
injectionTenoxicam Anti-inflammatory
Compatible 5 mg/ml + injectionThiocolchicoside 1 mg/ml + None
injectionThiocolchicoside Various
Compatible 0.57 mg/ml + injectionAcetylsalicylic acid lysinate 142.86 mg/ml + None
Compatible 1 mg/ml + injectionBetamethasone sodium phosphate 1 mg/ml + None
Compatible 1 mg/ml + injectionCyanocobalamine 1.25 mg/ml + None
Compatible 0.8 mg/ml + injectionDiclofenac 15 mg/ml + None
Compatible 1 mg/ml + injectionKetoprofene 25 & 40 mg/ml + None
Compatible 1.33 mg/ml + injectionKetorolac tromethamine 10 mg/ml + None
Compatible 1.33 mg/ml + injectionPiroxicam 6.67 mg/ml + None
Compatible 1 mg/ml + injectionTenoxicam 5 mg/ml + None
Stability of mixtures
Glass None 25°C Light
injection Piroxicam 6.6 mg/ml
injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C Light
injection Thiocolchicoside 1 mg/ml
injection Tenoxicam 5.2 mg/ml
3 Hour
Glass None 25°C
injection Ketoprofene 40 mg/ml
injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
injection Diclofenac 15 mg/ml
injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
injection Ketorolac tromethamine 10 mg/ml
injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
injection Acetylsalicylic acid lysinate 140 mg/ml
injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
injection Betamethasone sodium phosphate 1 mg/ml
injection Thiocolchicoside 1 mg/ml
3 Hour
Glass None 25°C
injection Thiocolchicoside 1 mg/ml
injection Cyanocobalamine 1.25 mg/ml
3 Hour

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