Last update :
19/11/2024
References   References 1833  
Type : Journal
Web link : https://doi.org/10.1345/aph.1D200

Research teams : Bondy - University Hospital Jean Verdier, Department of Pharmacy
Authors : Menard C, Bourguignon C, Schlatter J, Vermerie N.
Title : Stability of cyclophosphamide and mesna admixtures in polyethylene infusion bags.
Reference : Ann Pharmacotherapy ; 37, 12: 1789-1792. 2003

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
No comments for the degradation products

List of drugs
injectionCyclophosphamide Anticancer drug
Compatible 10.8 mg/ml + injectionMesna 3.2 mg/ml + Glucose 5%
Compatible 1.8 mg/ml + injectionMesna 0.54 mg/ml + Glucose 5%
injectionMesna Cytoprotective
Compatible 3.2 mg/ml + injectionCyclophosphamide 10.8 mg/ml + Glucose 5%
Compatible 0.54 mg/ml + injectionCyclophosphamide 1.8 mg/ml + Glucose 5%
Stability of mixtures
Polyethylene Glucose 5% 22°C Light
injection Mesna 0,54 mg/ml
injection Cyclophosphamide 1,8 mg/ml
6 Hour
Polyethylene Glucose 5% 22°C Light
injection Mesna 3,2 mg/ml
injection Cyclophosphamide 10,8 mg/ml
24 Hour
Polyethylene Glucose 5% 4°C Not specified
injection Mesna 3,2 mg/ml
injection Cyclophosphamide 10,8 mg/ml
48 Hour
Polyethylene Glucose 5% 4°C Not specified
injection Mesna 0,54 mg/ml
injection Cyclophosphamide 1,8 mg/ml
48 Hour

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