Last update :
06/05/2024
References   References 1806  
Type : Journal

Research teams : Ottawa - The Ottawa Hospital, department of Pharmacy
Authors : Donnely RF.
Title : Chemical stability of dimenhydrinate in minibags and polypropylene syringes.
Reference : Can J Hosp Pharm ; 55, 5: 307-312. 2002

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionDimenhydrinate Antihistamine (H1)
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 >> 2 mg/ml 22°C Light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 >> 2 mg/ml 4°C Protect from light
91 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 2,5 >> 10 mg/ml 22°C Light
60 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 2,5 >> 10 mg/ml 4°C Protect from light
60 Day

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