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References   References 1730  
Type : Journal
Research teams : Malmö - Malmö General Hospital
Authors : Björkman S, Roth B.
Title : Chemical compatibility of mitoxantrone and etoposide (VP-16).
Reference : Act Pharm Nord ; 3: 251. 1991
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products
List of drugs
InjectionEtoposide Anticancer drug
Compatible 0,5 & 10 mg/ml + InjectionMitoxantrone dihydrochloride 0,05 & 1 mg/ml + Sodium chloride 0,9%
InjectionMitoxantrone dihydrochloride Anticancer drug
Compatible 0,05 & 1 mg/ml + InjectionEtoposide 0,5 & 10 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Not specified None 25°C Protect from light
Injection Mitoxantrone dihydrochloride 1 mg/ml
Injection Etoposide 10 mg/ml
22 Hour
Not specified None 25°C Protect from light
Injection Mitoxantrone dihydrochloride 0,05 mg/ml
Injection Etoposide 0,5 mg/ml
22 Hour
  Mentions Légales