Last update :
19/11/2024
References   References 1723  
Type : Journal

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Sattler A, Jage J, Krämer I.
Title : Physico-chemical stability of infusion solutions for epidural administration containing fentanyl and bupivacaine or lidocaine.
Reference : Pharmazie ; 53: 386-391. 1998

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionFentanyl citrate Analgesic
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 25°C-30°C Light
injection Bupivacaine hydrochloride 0,59 & 1,25 mg/ml
injection Fentanyl citrate 2 µg/ml
32 Day
Polyvinyl chloride Sodium chloride 0,9% 4-8°C Protect from light
injection Bupivacaine hydrochloride 0,59 & 1,25 mg/ml
injection Fentanyl citrate 2 µg/ml
32 Day

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