Last update :
19/11/2024
References   References 1659  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA, Williams KY.
Title : Compatibility and stability of linezolid injection admixed with three cephalosporin antibiotics.
Reference : J Am Pharm Assoc ; 40: 509-514. 2000

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionCefazolin sodium Antibiotic
Compatible 10 mg/ml + injectionLinezolid 2 mg/ml + None
injectionCeftazidime Antibiotic
Compatible 20 mg/ml + injectionLinezolid 2 mg/ml + None
injectionCeftriaxone disodium Antibiotic
Incompatible 10 mg/ml + injectionLinezolid 2 mg/ml + None
injectionLinezolid Antibiotic
Compatible 2 mg/ml + injectionCefazolin sodium 10 mg/ml + None
Compatible 2 mg/ml + injectionCeftazidime 20 mg/ml + None
Incompatible 2 mg/ml + injectionCeftriaxone disodium 10 mg/ml + None
Stability of mixtures
Polyolefine None 23°C Protect from light
injection Linezolid 2 mg/ml
injection Cefazolin sodium 10 mg/ml
3 Day
Polyolefine None 23°C Protect from light
injection Linezolid 2 mg/ml
injection Ceftazidime 20 mg/ml
24 Hour
Polyolefine None 4°C Protect from light
injection Linezolid 2 mg/ml
injection Cefazolin sodium 10 mg/ml
7 Day
Polyolefine None 4°C Protect from light
injection Linezolid 2 mg/ml
injection Ceftazidime 20 mg/ml
7 Day

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