Last update :
18/07/2024
References   References 1658  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Xu QA, Trissel LA, Willimas KY.
Title : Compatibility and stability of linezolid injection admixed with aztreonam or piperacillin sodium.
Reference : J Am Pharm Assoc ; 40: 520-524. 2000

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionAztreonam Antibiotic
Compatible 20 mg/ml + injectionLinezolid 2 mg/ml + None
injectionLinezolid Antibiotic
Compatible 2 mg/ml + injectionAztreonam 20 mg/ml + None
Compatible 2 mg/ml + injectionPiperacillin sodium 30 mg/ml + None
injectionPiperacillin sodium Antibiotic
Compatible 30 mg/ml + injectionLinezolid 2 mg/ml + None
Stability of mixtures
Polyolefine None 23°C Protect from light
injection Linezolid 2 mg/ml
injection Piperacillin sodium 30 mg/ml
3 Day
Polyolefine None 23°C Protect from light
injection Linezolid 2 mg/ml
injection Aztreonam 20 mg/ml
7 Day
Polyolefine None 4°C Protect from light
injection Linezolid 2 mg/ml
injection Aztreonam 20 mg/ml
7 Day
Polyolefine None 4°C Protect from light
injection Linezolid 2 mg/ml
injection Piperacillin sodium 30 mg/ml
7 Day

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