Last update :
19/11/2024
References   References 1635  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/59/14/1351

Research teams : Montpellier - Oncopharmacology Laboratory, Val D'Aurelle Cancer Center
Authors : El Aatmani M, Poujol S, Astre C, Malosse F, Pinguet F.
Title : Stability of dacarbazine in amber glass vials and polyvinyl chloride bags.
Reference : Am J Health-Syst Pharm ; 59: 1351-1356. 2002

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
injectionDacarbazine Anticancer drug
Stability in solutions Glass Water for Injection 11 mg/ml 2-6°C Protect from light
7 Day
Stability in solutions Glass Water for Injection 11 mg/ml 20-25°C Protect from light
96 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 1,4 mg/ml 2-6°C Protect from light
168 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 1,4 mg/ml 20°C-25°C Protect from light
72 Hour

  Mentions Légales