Last update :
19/11/2024
References   References 163  
Type : Journal

Research teams : Exeter - University of Exeter
Authors : Sewell GJ, Allsopp M, Collinson MP, Tyrrell C, Prentice AJ, Copplestone JA.
Title : Stability studies on admixtures of 5-fluorouracil with carboplatin and 5-fluorouracil with heparin for administration in continuous infusion regimens.
Reference : J Clin Pharm Ther ; 19: 127-133. 1994

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
injectionCarboplatin Anticancer drug
Incompatible 100 mg/ml + injectionFluorouracil 1000 mg/ml + Glucose 5%
injectionFluorouracil Anticancer drug
Incompatible 1000 mg/ml + injectionCarboplatin 100 mg/ml + Glucose 5%
Compatible 24 mg/ml + injectionHeparin sodium 960 UI/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 960 UI/ml + injectionFluorouracil 24 mg/ml + Glucose 5%
Stability of mixtures
Polypropylen Syringe None 37°C Not specified
injection Heparin sodium 960 UI/ml
injection Fluorouracil 24 mg/ml
7 Day
Polypropylen Syringe None 4°C Protect from light
injection Heparin sodium 960 UI/ml
injection Fluorouracil 24 mg/ml
14 Day

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