Last update :
08/05/2024
References   References 1622  
Type : Journal

Research teams : Nimes - Caremeau Hospital, Pharmacy Department
Authors : Favier M, De Casanove F, Coste A, Cherti N, Bressolle F.
Title : Stability of carmustine in polyvinyl chloride bags and polyethylene-lined trilayer plastic containers.
Reference : Am J Health-Syst Pharm ; 58: 238-241. 2001

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products identified and quantified
No visual inspection
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionCarmustine Anticancer drug
Stability in solutions Glass Glucose 5% 0,1 & 0,5 mg/ml 4°C Protect from light
12 Hour
Stability in solutions Glass Glucose 5% 0,1 > 1 mg/ml 25°C Protect from light
2 Hour
Stability in solutions Glass Glucose 5% 1 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyethylene Glucose 5% 0,1 mg/ml 25°C Protect from light
2 Hour
Stability in solutions Polyethylene Glucose 5% 0,1 & 0,5 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyethylene Glucose 5% 0,5 & 1 mg/ml 25°C Protect from light
4 Hour
Stability in solutions Polyethylene Glucose 5% 1 mg/ml 4°C Protect from light
12 Hour

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