Last update :
19/11/2024
References   References 1605  
Type : Journal

Research teams : Athens - University of Georgia, College of Pharmacy
Authors : Stewart JT, Maddox FC, Warren FW.
Title : Stability of cefepime hydrochloride injection and metronidazole in polyvinyl chloride bags at 4°C and 22-24°C.
Reference : Hosp Pharm ; 35: 1057-1064. 2000

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionCefepime dihydrochloride Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 2,5/5/10/20 mg/ml 4°C Light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 20 mg/ml 22°C-24°C Light
3 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 10 mg/ml 22°C-24°C Light
1 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2,5 mg/ml 22°C-24°C Light
6 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 mg/ml 22°C-24°C Light
3 Day
Stability in solutions Polyvinyl chloride Glucose 5% 10 mg/ml 22°C-24°C Light
2 Day
Stability in solutions Polyvinyl chloride Glucose 5% 2,5 mg/ml 22°C-24°C Light
4 Day
Stability in solutions Polyvinyl chloride Glucose 5% 5 mg/ml 22°C-24°C Light
1 Day
injectionMetronidazole Antiparasitic
Stability of mixtures
Polyvinyl chloride None 22°C-24°C Light
injection Metronidazole 5 mg/ml
injection Cefepime dihydrochloride 2,5 & 20 mg/ml
2 Day
Polyvinyl chloride None 22°C-24°C Light
injection Metronidazole 5 mg/ml
injection Cefepime dihydrochloride 5 mg/ml
4 Day
Polyvinyl chloride None 22°C-24°C
injection Cefepime dihydrochloride 10 mg/ml
injection Metronidazole 5 mg/ml
5 Day
Polyvinyl chloride None 4°C Light
injection Cefepime dihydrochloride 2,5 >> 20 mg/ml
injection Metronidazole 5 mg/ml
7 Day

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