Last update :
19/11/2024
References   References 157  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA, Martinez JF.
Title : Stability of paclitaxel in 5% dextrose injection or 0.9% sodium chloride injection at 4, 22, or 32°C.
Reference : Am J Hosp Pharm ; 51: 3058-3060. 1994

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionPaclitaxel Anticancer drug
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 22°C Not specified
3 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 32°C Not specified
3 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml 4°C Protect from light
3 Day

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