Last update :
03/05/2024
References   References 154  
Type : Journal

Research teams : Lawrence - The University of Kansas, Department of Pharmaceutical Chemistry
Authors : Al-Razzak LA, Benedetti AE, Waugh WN, Stella VJ.
Title : Chemical stability of pentostatin (NSC-218321), a cytotoxic and immunosuppressant agent.
Reference : Pharm Res ; 7: 452-460. 1990

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No visual inspection

List of drugs
InjectionPentostatin Anticancer drug
Factors which affect stability PH PH < 5 Induces Degradation
Stability in solutions Glass Sodium chloride 0,9% 0.002 >> 0.02 mg/ml 22°C-23°C Not specified
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 2 mg/ml 22°C-23°C Not specified
72 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0.002 >> 0.02 mg/ml 22°C-23°C Not specified
48 Hour

  Mentions Légales