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References   References 152  
Type : Journal
Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Chevrier R, Sautou V, Pinon V, Demecop F, Chopineau J.
Title : Stability and compatibility of a mixture of the anti-cancer drugs etoposide, cytarabine and daunorubicine for infusion.
Reference : Pharm Acta Helv ; 70: 141-148. 1995
Level of Evidence : 
Joker
Level of Evidence : 
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No comments for the degradation products
List of drugs
injectionCytarabine Anticancer drug
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 25°C With or without light
48 Hour
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 4°C With or without light
48 Hour
injectionDaunorubicin hydrochloride Anticancer drug
Stability in solutions Polypropylene Glucose 5% 0,0157 mg/ml 25°C With or without light
48 Hour
Stability in solutions Polypropylene Glucose 5% 0,0157 mg/ml 4°C With or without light
48 Hour
injectionEtoposide Anticancer drug
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 25°C With or without light
48 Hour
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 4°C With or without light
48 Hour
Stability of mixtures
Polypropylene Glucose 5% 25°C With or without light
injection Etoposide 0,157 mg/ml
injection Cytarabine 0,157 mg/ml
injection Daunorubicin hydrochloride 0,0157 mg/ml
48 Hour
Polypropylene Glucose 5% 4°C Protect from light
injection Etoposide 0,157 mg/ml
injection Cytarabine 0,157 mg/ml
injection Daunorubicin hydrochloride 0,0157 mg/ml
48 Hour
  Mentions Légales