Last update :
18/04/2024
References   References 1475  
Type : Journal
Web link : https://doi.org/10.1016/0731-7085(95)01635-X

Research teams : Montpellier - Oncopharmacology Laboratory, Val D'Aurelle Cancer Center
Authors : Martel P, Petit I, Pinguet F, Poujol S, Astre C, Fabbro M.
Title : Long-term stability of 5-fluorouracil stored in PVC bags and in ambulatory pump reservoirs.
Reference : J Pharm Biomed Anal ; 14: 395-399. 1996

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
No comments for the degradation products
Stability indicating capability inadequately assessed

List of drugs
InjectionFluorouracil Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 10 mg/ml 21°C Light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 10 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride None 50 mg/ml 33°C Protect from light
14 Day
Stability in solutions Ethylene vinyl acetate None 50 mg/ml 33°C Protect from light
14 Day

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