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References   References 146  
Type : Journal
Research teams : Marseille - Valvert Hospital, Department of Pharmacy
Authors : Hadji-Minaglou-Gonzalvez MF, Gayte-Sorbier A, Airauto CB, Verdier M.
Title : Effects of temperature, solution composition, and type of container on the stability and absorption of carmustine.
Reference : Clin Ther ; 14: 821-824. 1992
Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products
List of drugs
injectionCarmustine Anticancer drug
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,96 mg/ml 22°C Protect from light
3 Hour
Stability in solutions Glass Sodium chloride 0,9% 0,96 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Glass Glucose 5% 0,96 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,96 mg/ml 22°C Protect from light
3 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,96 mg/ml 4°C Protect from light
48 Hour
  Mentions Légales