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References   References 1421  
Type : Journal
Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Johnson CE, Truong NM.
Title : Stability and compatibility of tacrolimus and fluconazole in 0.9% sodium chloride.
Reference : J Am Pharm Assoc ; 39: 505-509. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionFluconazole Antifungal
Compatible 0,5 & 1,5 mg/ml + injectionTacrolimus 5 & 20 µg/ml + Sodium chloride 0,9%
injectionTacrolimus Immunosuppressant
Compatible 5 & 20 µg/ml + injectionFluconazole 0,5 & 1,5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 23°C-25°C Light
injection Tacrolimus 5 & 20 µg/ml
injection Fluconazole 0,5 & 1,5 mg/ml
3 Hour
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